Abstract
The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the D-diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.
MeSH terms
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Bone Morphogenetic Protein 1
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Bone Morphogenetic Proteins / antagonists & inhibitors*
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Hydroxamic Acids / chemical synthesis*
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Hydroxamic Acids / pharmacology*
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Indicators and Reagents
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Kinetics
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Metalloendopeptidases / antagonists & inhibitors*
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Protease Inhibitors / chemical synthesis*
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Protease Inhibitors / pharmacology*
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Structure-Activity Relationship
Substances
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Bone Morphogenetic Proteins
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Hydroxamic Acids
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Indicators and Reagents
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Protease Inhibitors
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Metalloendopeptidases
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Bone Morphogenetic Protein 1